Coronary artery diseaseMeta-Analysis of Studies of Patients in the United Arab Emirates With ST-Elevation Myocardial Infarction Treated With Thrombolytic Agents
Section snippets
Methods
From 1995 through 2009 we participated in 4 international, multicenter, randomized, controlled, clinical trials and 2 collaborative studies with the University of Vermont, Burlington, in which pharmacologic thrombolysis for treatment of acute STEMI was employed with alteplase (tissue plasminogen activator [t-PA]) or tenecteplase (TNK). The first of the randomized trials was the Continuous Infusion Versus Double Bolus Alteplase (COBALT) study.3 The other 3 were the Assessment of the Safety and
Discussion
Our results show strikingly low early morbidity and mortality after treatment with t-PA or TNK. Our patients were quite young, a feature likely to contribute to the low mortality. Mortality data from ASSENT III6 were higher than in the other studies (6.52% vs 1.27% to 3.21%), although patient demographics were similar. This was not statistically significant because of the small number of patients (Table 5). Our patients were predominantly men and treated promptly (within an average of 3.5 hours
Acknowledgment
We thank Vasanta Lakshmi, PGDHA, for her transcription services and the entire team of the coronary care unit and emergency department of Rashid Hospital.
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Cited by (5)
Biosimilarity. Do not confuse biosimilar and biocopy. Example of tenecteplase
2023, Annales Pharmaceutiques FrancaisesComparison of characteristics, management practices, and outcomes of patients between the global registry and the gulf registry of acute coronary events
2011, American Journal of CardiologyCitation Excerpt :Potential explanations for the higher rates of short-term complications in Gulf RACE include differences in the receipt of different treatment procedures and more prolonged delays in seeking medical care.21 Similar findings to our study were observed in a meta-analysis based on data from the Gulf region, which found that most patients with STEMI were managed by thrombolytics and had favorable outcomes.22 A study comparing patients enrolled in the United States to their Canadian counterparts in the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries I (GUSTO-I) trial reported that, despite a greater use of invasive cardiac procedures in the United States, favorable outcomes were observed only when comparing long-term mortality rates, although short-term mortality rates were comparable.23
Fibrinolysis in acute myocardial infarction: State of the art research
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